ea0008oc19 | Young Endocrinologist Session | SFE2004
Marsh VB
, Kola B
, Hanson M
, Emery M
, Musat M
, Bonner S
, Khalaf S
, Norman D
, Grossman A
, Korbonits M
Background: Ghrelin was recently discovered as the natural ligand for the G protein-coupled growth hormone secretagogue receptor and induces GH release through GHS-R1a. The octanoylation of its third serine residue is responsible for GH release and receptor binding. A variant of ghrelin devoid of this modification, desoctanoyl-ghrelin, can neither bind to the receptor nor induce GH release. Ghrelin has also been shown to effect cellular proliferation, being pro-proliferative i...